More and more hotels are offering “pure rooms” or “hypoallergenic rooms” that are largely free of chemicals and allergens. A number of hotels, from the Fairmont Vancouver Airport Hotel to the Premier Hotel in Times Square, are testing out “hypoallergenic rooms.” While there is no set standard for hypoallergenic rooms, most use air purifiers, natural antiseptics, and even ozone mists to minimize bacteria and dust mites. So while the rooms may not be allergen-free, most allergens will be significantly reduced.

But all this specialized cleaning comes at a cost at most hotels. At the Annapolis Waterfront Marriott, for example, there’s an extra $20 charge for “Pure rooms.” Hotels run by Thayer Lodging, which runs some Marriott, Hilton, Doubletree and Wyndham properties, charge a 5 to 10% premium for their “Pure rooms.” But for severe allergy-sufferers, twenty dollars or so may be a great price for having a sneeze-free night.